Atopic Dermatitis: a Short Summary
- Soy contains antioxydants calles isoflavones. The 2 main ones are genistein and daizedine.
- In this study, the authors studied 7,3’,4’-Trihydroxyisoflavone (7,3’,4’-THIF), a metabolite of daidzedine would have a depigmenting effect
- Contrarily to daizedine, 7,3’,4’-THIF inhibits the extracellular and intracellular production of melanin by B16F10 cells (induced by α-melanocyte-stimulating hormone (MSH))
- (7,3’,4’-THIF), abolished the expression of tyrosinase et de tyrosinase-related protein 1 (TRP-1).
- 7,3’,4’-THIF abolished the expression of transcription factors intervening in the activation of tyrosinase: Microphthalmia-associated transcription factor (MITF), cAMP response element-binding (CREB)
- Other results show that 7,3’,4’-THIF acts by targetting the mélanocortin 1 receptor (MC1R), and this subsequently inhibits the production of melanin.
- Comment: The study is done in vitro, not in vivo
Contributors:
Dr Christophe HSU – dermatologist. Geneva, Switzerland
Source of Information: 7,3′,4′-Trihydroxyisoflavone, a metabolite of the soy isoflavone daidzein, suppresses α-MSH-induced Melanogenesis by targeting Melanocortin 1 receptor. J Kim,1 Y Kim,1 J Kim,1 J Park,2 D Kim,2 M Yeom,2 AM Bode,3 Z Dong,3 H Lee,4 K Lee4,5 and N Kang1 1School of Applied Biosciences, Kyungpook National University, Daegu, Republic of Korea, 2Skin Research Institute, Amorepacific Corporation R&D Center, Yongin, Republic of Korea, 3The Hormel Institute, University of Minnesota, Minnesota, MN, 4WCU Biomodulation Major, Department of Agricultural Biotechnology, Seoul National University, Seoul, Republic of Korea and 5Advanced Institutes of Convergence Technology, Seoul National University, Seoul, Republic of Korea. International Investigative Dermatology (IID) 2013 – Edinburgh, United Kingdom
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