Atopic Dermatitis: a Short Summary
-Polymorphous Light Eruption (PMLE):
-appearance more papular in darker skin
-PML patients are more resistant to UV-induced immunosuppression. Explains the “Hardening Concept”: desentisization treatment with UV light: enables immunotolerance
-Voriconazole (antifungal): has been shown to induce developement of erythema, lentigenes, squamous cell carcinoma and melanoma
–Vemurafenib (BRAF inhibitor used for the treatment of metastatic melanoma): 15-30% of patients develop SCC and Keratoacanthoma (ras mutation induction). After phototesting, it is shown that the UV light implicates is UVA (UVB effect is suppressed)
Keratoacanthoma
Contributors:
Dr Christophe HSU – dermatologist. Geneva, Switzerland
Source of information: Lim H. Advances on Photodermatology. 2012 (02) – 20th Regional Conference of Dermatology (RCD) – Manila, Phillipines
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